A blood-clotting protein performs a brand new position in repairing broken blood vessels.
Analysis by the College of Drugs and Well being Sciences RCSI has uncovered a brand new position for the blood clotting protein, von Willebrand issue (VWF), which might result in the event of recent remedies for sufferers with inflammatory and blood clotting problems.
Posted in Nature Communicationanalysis reveals that VWF performs an necessary position in regulating immune responses to websites of blood vessel damage. This implies the protein has a newly found position in repairing broken blood vessels, along with its position in blood clotting.
VWF deficiency known as ‘von Willebrand’s illness’ and impacts round 1 in 1,000 individuals in Eire. Individuals with this illness have an elevated threat of extreme bleeding. Alternatively, individuals with excessive ranges of this protein within the blood are susceptible to creating critical blood clots. For instance, very excessive ranges of VWF have been implicated within the uncommon blood clots seen within the lungs of sufferers with extreme COVID-19.
This analysis reveals, for the primary time, that VWF not solely regulates blood clotting on the web site of damage but additionally triggers native immune responses. Understanding this novel organic position of VWF in regulating inflammatory responses might present the chance to develop fully new therapeutic choices for sufferers with inflammatory and blood clotting problems, comparable to von Willebrand’s illness, deep vein thrombosis and myocardial infarction.
For greater than 50 years, von Willebrand issue has been recognized to play a key position in stopping bleeding by appearing as glue on the web site of damage. This analysis is now serving to us to higher perceive the position that VWF performs within the hyperlink between blood clotting and irritation and thus paves the way in which for the event of recent remedies. »
Professor James O’Donnell, lead writer, Director of the Irish Middle for Vascular Biology, RCSI College of Pharmacy and Biomolecular Sciences.
The analysis was carried out by RCSI in collaboration with Trinity School Dublin and the Nationwide Coagulation Middle at St James’s Hospital Dublin.
The examine was funded by Science Basis Eire and the US Nationwide Institutes of Well being (NIH).
Drakeford, C. et al. (2022) Von Willebrand issue hyperlinks major hemostasis to innate immunity. Communication Nature. doi.org/10.1038/s41467-022-33796-7.
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