A treatment for autism spectrum disorders could finally see the light of day

A treatment for autism spectrum disorders could finally see the light of day

Autism spectrum disorder can manifest in many forms at varying intensities. So far, there is no no effective treatment to cure him. But lately, a key clue has been uncovered by researchers from the Daegu Gyeongbuk Institute of Science and Technology.

A treatment for autism spectrum disorders could finally see the light of day

Indeed, the research led by Professor Kim Min-sik of the Department of New Biology has paid off. These Korean scientists have identified the molecular network specific to autism spectrum disorder cells.

This discovery could lift the veil on autism spectrum disorder and allow lay the groundwork for treating it effectively.

Current diagnostic and treatment methods are still incomplete

Autism spectrum disorder is a developmental disorder known to manifest itself in early childhood. It is characterized by a continuous impairment of the social communication and interaction behaviors. Autistic children most often have difficulty babbling, listening, smiling, making communicative gestures, etc. This results in a limited range of behaviors, interests, and activities, as well as repetitive behaviors.

Most of the time, these behavioral problems are accompanied by other developmental disorders in people with this disease. So far, no precise molecular diagnostic method has been found. This implies that early diagnosis must be made at a fairly late period. While behavioral management therapy currently improves symptoms, an effective treatment that could work at the molecular level.

Researchers finally discover the origin of the problem

Professor Kim Min-sik used a mouse with spectrum disorder. First, he and his team proceeded to protein analysis of a tissue extract from the prefrontal cortex. Subsequently, they proceeded to a metabolomic analysis which is used to discover the identity and quantity of small molecules in the tissue. These two integrated quantitative analyzes are based on the mass spectrometry.

For the next step, the scientists compared and analyzed these data with previous reports of patients with autism spectrum disorders. This is where the researchers got confirmation that the problems occur in networks like metabolism and synapses of excitable neurons.

“The multi-omics integrated analysis technology developed in this study has advanced the pathological understanding of autism spectrum disorders and uncovered an integrated network ranging from cellular differentiation to the molecular level induced by a gene specific to autism to biometric information. We try to find the central network of autism spectrum disorders and discover therapeutic targets by performing an integrated analysis of various models. »

Kim Min Sik


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