Does double vaccination against influenza and COVID-19 provide additional protection against COVID-19?
The results of a study suggest that the double vaccination against influenza/COVID-19 increases protection against the severe form of COVID-19.
- Double vaccination against influenza and COVID-19 increases protection against SARS-CoV-2 infections, compared to no vaccination.
Why is this important?
- Encourage series of primary and booster vaccinations against seasonal influenza and COVID-19, highlighting the potential boost in protection against serious SARS-CoV-2 infections.
- 21,387 adults, ages 18 and older, made up the unweighted sample selected to represent 185,251,310 adults in the United States, the weighted sample.
- Overall, 42.5% of the weighted population received both vaccines, while nearly a quarter of the population (22.4%) was unvaccinated.
- 6% of the population received the flu vaccination only; about 30% of the population received the vaccination against COVID-19 only.
- People who received both vaccines were mostly women aged 65 or older, reported good/poor health and at least 2 comorbidities.
- Double-vaccinated people had the lowest rate of SARS-CoV-2 infection (11.4%), as multivariate analysis showed that respondents who received the COVID-19 vaccination only or the double vaccination were less likely to report SARS-CoV-2 infection than unvaccinated people.
- 8.0% of people who reported SARS-CoV-2 infections were asymptomatic, about 35% to 38% had a mild to moderate form, and 19.6% had a severe form.
- A retrospective secondary analysis investigated the association between COVID-19 and seasonal influenza double vaccination status on the one hand and the severity of SARS-CoV-2 infection/COVID-2 symptoms. 19 on the other hand, using data from the 2021 US National Health Interview Survey.
- Funding: no funding has been communicated.
- Self-report and recall bias.
- Possibility of underestimated associations between vaccination status and COVID-19 due to asymptomatic infections.
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