Health

The HAS recommends a vaccination marketing campaign in opposition to…

The HAS recommends a vaccination marketing campaign in opposition to…

The Haute Autorité de Santé (HAS) has up to date its suggestions referring to the booster vaccination technique in opposition to covid 19. They had been posted on-line on September 20, 2022 in three opinions:

  1. Booster vaccine technique in opposition to covid 19;
  2. Vaccination technique in opposition to covid 19 – Place of the bivalent Spikevax Authentic/Omicron BA.1 vaccine (mRNA-1273.214);
  3. Vaccination technique in opposition to covid 19 – Place of the Comirnaty bivalent vaccines Authentic/Omicron BA.1 and Authentic/Omicron BA.4-5.

In these texts, the HAS recommends:

  • the group of a vaccination marketing campaign in opposition to covid 19 within the fall of 2022, throughout which a booster dose with a bivalent vaccine tailored to the Omicron variant (whatever the variety of boosters already administered beforehand) have to be supplied to folks prone to extreme type of covid 19 in addition to these round them;
  • the coupling of this marketing campaign with the vaccination marketing campaign in opposition to seasonal influenza

All of the suggestions contained on this latest opinion are detailed beneath.

1. Reminder on bivalent vaccines

Three bivalent vaccines appropriate for the Omicron variant had been approved by the European Medicines Company (EMA) in September 2022

  • Bivalent Spikevax Authentic/Omicron BA.1 (Moderna laboratory): 25 μg of mRNA encoding the spike protein of the Wuhan pressure contained within the authentic Spikevax vaccine and 25 μg of the identical tailored mRNA containing the coding sequence of the spike protein of the BA.1 sub-line of the Omicron variant (MA variation accepted by the EMA on September 1, 2022);
  • Comirnaty bivalent Authentic/Omicron BA.1 15/15 μg (Pfizer-BioNTech laboratory): two SARS-CoV-2 mRNAs, one encoding the spike protein of the unique Wuhan pressure and the opposite encoding the spike protein the BA.1 subline of the Omicron variant (MA variation accepted by the EMA on September 1, 2022);
  • Comirnaty bivalent Authentic/Omicron BA.4-BA.5 15/15 μg (Pfizer-BioNTech laboratory): two SARS-CoV-2 mRNAs, one encoding the spike protein of the unique Wuhan pressure and the opposite encoding a standard sequence of the spike protein of the BA.4 and BA.5 sublines of the Omicron variant (MA variation accepted by the EMA on September 12, 2022).

2. Up to date suggestions from the French Nationwide Authority for Well being

HAS has revealed the next suggestions.

2.1. Proceed the second booster marketing campaign (most frequently a fourth dose) for folks prone to affected by a extreme type of the illness, in addition to for these round them and healthcare professionals:

  • folks aged 60 and over;
  • residents of lodging institutions for dependent aged folks (EHPAD) and long-term care items (USLD);
  • immunocompromised folks, no matter their age (nevertheless, bivalent vaccines are usually not approved earlier than the age of 12);
  • adults aged 18 to 59 recognized as being prone to a extreme type of covid 19;
  • kids and adolescents at excessive danger, and affected by pathologies justifying it;
  • pregnant ladies, from the first trimester of being pregnant;
  • folks dwelling round or in common contact with weak or immunocompromised folks, in a cocooning technique;
  • healthcare professionals, no matter their age or state of well being;
  • all workers within the well being and medico-social sector, house helpers working with weak folks, medical transport professionals, in addition to firefighters, no matter their age, their mode of train or their state of well being.

For reminiscence :

  • this second reminder is really helpful:
    – 3 months after the primary booster for folks aged 80 and over, in addition to for residents of nursing houses or USLDs and severely immunocompromised folks, no matter their age;
    – from 6 months after the primary reminder for different eligible individuals.
  • for individuals who have been contaminated with SARS-CoV-2, an extra booster dose continues to be really helpful, respecting a minimal interval of three months after an infection.
  • so long as bivalent vaccines are usually not obtainable, don’t hesitate to hold out the second booster with a “standard” vaccine.

2.2. Arrange a vaccination marketing campaign in opposition to covid 19 within the fall of 2022 with bivalent vaccines

HAS recommends that, throughout this marketing campaign:

For folks below 30 years of age, HAS recommends preferential use of Comirnaty bivalent Authentic/Omicron BA.1 15/15 μg or Comirnaty bivalent Authentic/Omicron BA.4-BA.5 15/15 μg vaccines for the autumn marketing campaign.

Essentially the most fragile folks will obtain the bivalent vaccine as a precedence. A ample variety of doses have been ordered, and all folks eligible for a booster vaccine in opposition to covid 19 (whether or not it’s a first, a second or a 3rd booster) will be capable of obtain a bivalent vaccine. . The bivalent Spikevax Authentic/Omicron BA.1 vaccine will likely be obtainable for order as of September 26, 2022.

2.3. Couple this reminder marketing campaign in opposition to covid 19 with the vaccination marketing campaign in opposition to seasonal flu

Within the absence of an epidemic wave linked to covid 19 within the coming weeks, the beginning date of the vaccination marketing campaign in opposition to covid 19 needs to be decided by the beginning date of vaccination in opposition to seasonal influenza, particularly Tuesday 18 October 2022.

The HAS remembers that:

  • simultaneous administration of vaccines in opposition to influenza and covid 19 is feasible: the 2 injections might be carried out on the identical day, however at two separate vaccination websites (one vaccine in every arm);
  • for individuals who don’t obtain the booster dose in opposition to covid 19 (or for that matter a primary or second dose of this vaccine) and the flu injection concurrently, there isn’t any time restrict to respect between the 2 vaccinations; this rule additionally applies to any affiliation between vaccines in opposition to covid 19 and different vaccines within the vaccination schedule.

2.4. To enhance vaccination protection, which continues to be inadequate, and to proceed research in Courses

As of September 15, 2022, the vaccination protection of individuals eligible for the second booster dose was solely 32.9% amongst 60-79 12 months olds and 46.2% amongst 80 12 months olds and over.

2.5. As well as, the HAS insists on:

  • The truth that sufferers most prone to a extreme type of Covid-19 and, particularly, immunocompromised folks or folks with a really high-risk pathology no matter their age, and sufferers over 65 years outdated with danger elements prone to growing severe kinds, should be capable of profit from preventive therapy with Paxlovid, no matter their vaccination standing, as already really helpful upfront by the HAS.
  • The significance of sustaining barrier gestures, together with after vaccination.
  • The truth that the research in progress must be continued so as to have the ability to have longer-term immunogenicity, efficacy and tolerance information, in addition to within the pediatric inhabitants, and needs to be told of any new outcomes.

Lastly, HAS regrets the absence of direct comparative information (medical or pre-clinical) to check the immunogenicity of the completely different bivalent vaccines tailored to the variants.

A subsequent model of the vaccine determination assist system will quickly be obtainable on MesVaccins.internet: this model will bear in mind the dates of sure circumstances (date of onset of being pregnant, date of SARS-CoV-2 an infection ) and their intervals in relation to potential vaccinations.

Supply : Excessive Authority of Well being.


#recommends #vaccination #marketing campaign #in opposition to..

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *

Back to top button